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Group B consisted of men receiving 600mg of testosterone enanthate in injection form every single week. The other three groups received placebo and placebo-containing capsules at the same time. The first two groups were chosen from the same population of men as those who had not yet stopped taking hormonal contraception. The third group was composed of men who had experienced a previous fallopian tube rupture (n = 9). The purpose of this study was to assess both the side-effects and the efficacy of this new transdermal testosterone solution against the symptoms of polycystic ovarian syndrome (PCOS) on the basis of a prospective, double blind, placebo controlled, prospective, randomized, double blind, placebo controlled study. A total of 100 men participated in this study. RESULTS: The mean age was 50.7 ± 7.3 years, 61 men (52.7%) were premenopausal and 55 (61.2%) were postmenopausal. Mean BMI was 21.2 ± 1.2 kg/m2. All the men were diagnosed with PCOS in most cases (82.3%) and were undergoing hormonal therapies. The serum testosterone level was 3.7 ± 3.3 ng/mL and the free testosterone concentration was 17.0 ± 2.9 nmol/L. All the subjects were taking either oral contraceptives (48.0%), transdermal testosterone (24.5%), or nothing to treat the symptoms of PCOS. CONCLUSION: Our results confirm that this new transdermal testosterone solution is superior to standard testosterone tablets in the treatment of PCOS in the study with 100 men who had experienced a previous fallopian tube rupture. © 2014 Elsevier B.V. All rights reserved. Related Article:
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